The objective of present study was to evaluate the effect of a marketed Ayurvedic formulation Glucova, on serum glucose, cholesterol, triglyceride, high density lipoprotein, total protein, albumin, creatinine and urea in alloxan-induced diabetic rats. Alloxan-induced (120 mg/kg i.p.) diabetic rats were divided in 4 groups of 6 each. Vehicle, Glucova 300 mg/kg and Glibenclamide 4 mg/kg, was administered orally to group I and II (Normal and Diabetic control), group III (Treatment) and group IV (Standard) respectively for 21 days. Blood glucose level was estimated weekly. After treatment period of 21 days serum was estimated for glucose and other biochemical parameters. Glucova in a dose of 300 mg/kg orally produced significant reduction in blood glucose level compared to diabetic rats. It also significantly reduced the elevated levels of serum cholesterol, triglycerides, creatinine and urea and increased the decreased level of high density lipoproteins, total proteins and albumin levels in alloxan-induced diabetic rats. Thus Glucova is effective hypoglycemic and also restores the altered biochemical parameters in Diabetes Mellitus.
Loading....